A roadmap developed and deployed during a time of crisis.

Accelerating Diagnostics in a Time of Crisis: The Response to COVID-19 and a Roadmap for Future Pandemics chronicles our nation’s effort to combat the SARS CoV-2 virus and bring millions of Covid-19 diagnostic tests to market in a period of less than a year.

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About the Book

Despite the challenges inflicted by COVID-19 globally, the pandemic provided an opportunity to create and build an innovative and adaptive system that responded to each wave of the disease. This book provides a narrative of this response and draws from more than two years of data and protocols resulting in dozens of diagnostic tests and ground-breaking processes to address variant detection.


Co-authored by epidemiologists, virologists, immunologists, diagnosticians, molecular scientists, physicians, business executives, and other key opinion leaders who were real-time players in the pandemic response, this book is both a retrospective and prospective analysis, presenting lessons learned throughout the National Institute of Biomedical Imaging and Bioengineering’s (NIBIB) Rapid Acceleration of Diagnostics (RADx) Initiative.

The Pandemic Response Roadmap

Mapped to each chapter of the book, the roadmap provides a chronological encapsulation of tasks related to research, development, and commercialization of COVID-19 tests completed over a two-year period.

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Conversational in tone but rich in science, data, and intricate technical detail, Accelerating Diagnostics in a Time of Crisis is written for lay and scientific audiences alike. The chapters collectively present a behind-the-scenes chronology of events and discoveries that occurred in the wake of the pandemic and provide a guide for a future pandemic response.

The Book

Accelerating Diagnostics in a Time of Crisis

Co-authored by epidemiologists, virologists, immunologists, diagnosticians, molecular scientists, and other key opinion leaders who were real-time players in the pandemic response, this book is both a retrospective and prospective analysis, presenting lessons learned throughout the NIBIB’s Rapid Acceleration of Diagnostics (RADx) Initiative.

Buy the Book

"

The concept addresses the significant gap that exists in the timely development of diagnostics that are both reliable and fit for purpose, a subject I am very interested in. I am heartened that you have taken a multi-disciplinary approach to build a roadmap for the next pandemic.

Susie Braniff, Ph.D

Scientist, WHO, Invitro Diagnostic Assessment Team

"

I need to know what to do to protect people, my family and my co-workers. I’m interested in all the areas this book covers.

Mirna DiPano, Ph.D

VP of Regulatory Affairs for Nanotech Technologies

"

I believe your book can serve as an inspiration and guide to future innovators who face the next health crisis.

Harvey Fineberg, M.D., Ph.D

President, Gordon and Betty Moore Foundation

"

This book essentially reverse-engineers and then lays out the pathway that we were all involved in but we all failed to prepare for. This is a detailed, essential guide that provides a well-documented process for the managing our next pandemic.

J. Paul Robinson, Ph.D

Distinguished Professor of Cytometry, Purdue University

"

An outstanding blend of science, real-world insights, and practical guidance that will be of great interest for both the lay audience and scientists. The diverse voices and visual roadmaps make this book a comprehensive and actionable guide, leaving readers better equipped to face future pandemics.

David A. Hafler, M.D.

Neurologist-in-Chief, Yale New Haven Hospital
William S. and Lois Stiles Edgerly Professor of Neurology and Professor of Immunobiology
Chairman, Department of Neurology Yale School of Medicine

"

Those of us who lived and worked through the COVID-19 pandemic have a duty to document and provide a roadmap to those who follow us and may need to urgently respond to similar challenges. Accelerating Diagnostics in a Time of Crisis is an excellent resource for policy makers and those who are part of global public health responses.

Thomas N. Denny, MSc, M.Phil

Chief Operating Officer, Duke Human Vaccine Institute

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Explore the graphics

View all of the book’s figures in greater details.

Figure-1.2

Chapter 1 / Fig. 1.2

Pandemic Evolution: Early Detection to Declaration of a COVID-19 Pandemic.

graphic-new-01

Chapter 1 / Fig. 1.4

SARS-CoV-2 introductions to U.S. and Europe. Credit: Modified from Worobey M, Science, 2020.

SARS CoV-2 Structure

Chapter 2 / Fig. 2.2

SARS-CoV-2 Entry into Cell.

Immune Responses-03

Chapter 2 / Fig. 2.4

Multiple responses of a normal immune system.

9.2

Chapter 9 / Fig. 9.2

Emergence of SARS-CoV-2 VOCs.

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pandemicresponseroadmap@poctrn.org

This project has been funded in whole or in part with Federal funds from the NHLBI, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N92022D00013. The views expressed in the book and this website are those of the authors and do not necessarily represent the views of the National Institute of Biomedical Imaging and Bioengineering; the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.

© Pandemic Response 2024

Accelerating Diagnostics in a Time of Crisis and the Pandemic Response Roadmap chronicle our nation’s effort to combat the SARS CoV-2 virus and bring millions of Covid-19 diagnostic tests to market in fewer than 12 months, providing a rubric for a future pandemic response.

Buy the Book

Contact

pandemicresponseroadmap@poctrn.org 

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Copyright 2024