This review provides an introduction to an array of topics that pertain to different states of pandemic acuity: interpandemic preparedness, alert, surge activity, recovery and relapse through the literature and experience of recent pandemics including COVID-19, H1N1, Ebola, and SARS.
After the third year of the COVID-19 pandemic, most of the severe COVID-19 burden falls upon immunocompromised patients who cannot mount an endogenous immune response after both vaccination and/or natural infection. In this narrative review, the authors show that combinations of either small molecule antivirals or small molecule antiviral plus passive immunotherapies are safe and effective…
This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially…
This project has been funded in whole or in part with Federal funds from the NHLBI, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N92022D00013. The views expressed in the book and this website are those of the authors and do not necessarily represent the views of the National Institute of Biomedical Imaging and Bioengineering; the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.
© Pandemic Response 2024
Accelerating Diagnostics in a Time of Crisis and the Pandemic Response Roadmap chronicle our nation’s effort to combat the SARS CoV-2 virus and bring millions of Covid-19 diagnostic tests to market in fewer than 12 months, providing a rubric for a future pandemic response.
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