SARS-CoV-2 variant biology: immune escape, transmission and fitness

SARS-CoV-2 variant biology: immune escape, transmission and fitness

In this Review, the authors summarize the literature on the relative transmissibility and antigenicity of SARS-CoV-2 variants, the role of mutations at the furin spike cleavage site and of non-spike proteins, the potential importance of recombination to virus success, and SARS-CoV-2 evolution in the context of T cells, innate immunity and population immunity.