This review provides an introduction to an array of topics that pertain to different states of pandemic acuity: interpandemic preparedness, alert, surge activity, recovery and relapse through the literature and experience of recent pandemics including COVID-19, H1N1, Ebola, and SARS.
fter more than two years since the first report of COVID-19, it remains crucial to continue studying how SARS-CoV-2 proteins interact with the host metabolism to cause COVID-19. This review summarizes the findings regarding the functions of the 16 non-structural, 6 accessory and 4 structural SARS-CoV-2 proteins.
This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially…
The COVID variants Pirola (BA.2.86) as well as Eris (EG.5.1) are spreading faster and faster. Especially Pirola which seems to be even more easily transmissible than all other Corona mutations.
National governance may have influenced the response of institutions to the Covid-19 pandemic, being a key factor in preparing for the next pandemics. The objective was to analyze the association between excess mortality due to COVID-19 (daily and cumulative per 100 thousand people) and national governance indicators in 213 countries.
After the third year of the COVID-19 pandemic, most of the severe COVID-19 burden falls upon immunocompromised patients who cannot mount an endogenous immune response after both vaccination and/or natural infection. In this narrative review, the authors show that combinations of either small molecule antivirals or small molecule antiviral plus passive immunotherapies are safe and effective…
Researchers are actively pursuing the development of next-generation and universal influenza vaccines to provide comprehensive protection against potential pandemic subtypes or strains. This review outlines the critical challenges and advancements in research and development (R&D) and highlights the improvements in regulatory responses for influenza vaccines.
This project has been funded in whole or in part with Federal funds from the NHLBI, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N92022D00013. The views expressed in the book and this website are those of the authors and do not necessarily represent the views of the National Institute of Biomedical Imaging and Bioengineering; the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.
© Pandemic Response 2024
Accelerating Diagnostics in a Time of Crisis and the Pandemic Response Roadmap chronicle our nation’s effort to combat the SARS CoV-2 virus and bring millions of Covid-19 diagnostic tests to market in fewer than 12 months, providing a rubric for a future pandemic response.
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