Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. This review summarizes current information regarding presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types.
fter more than two years since the first report of COVID-19, it remains crucial to continue studying how SARS-CoV-2 proteins interact with the host metabolism to cause COVID-19. This review summarizes the findings regarding the functions of the 16 non-structural, 6 accessory and 4 structural SARS-CoV-2 proteins.
This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially…
The COVID variants Pirola (BA.2.86) as well as Eris (EG.5.1) are spreading faster and faster. Especially Pirola which seems to be even more easily transmissible than all other Corona mutations.
A Joint Letter to all WHO Member States: Now is the time to agree on a pandemic accord which safeguards everyone from pandemic threats. As eyes now focus on the Geneva processes to negotiate a pandemic accord and amend the International Health Regulations, the encourage WHO Member States to take this historic opportunity and successfully…
National governance may have influenced the response of institutions to the Covid-19 pandemic, being a key factor in preparing for the next pandemics. The objective was to analyze the association between excess mortality due to COVID-19 (daily and cumulative per 100 thousand people) and national governance indicators in 213 countries.
This review provides an introduction to an array of topics that pertain to different states of pandemic acuity: interpandemic preparedness, alert, surge activity, recovery and relapse through the literature and experience of recent pandemics including COVID-19, H1N1, Ebola, and SARS.
This project has been funded in whole or in part with Federal funds from the NHLBI, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N92022D00013. The views expressed in the book and this website are those of the authors and do not necessarily represent the views of the National Institute of Biomedical Imaging and Bioengineering; the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.
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Accelerating Diagnostics in a Time of Crisis and the Pandemic Response Roadmap chronicle our nation’s effort to combat the SARS CoV-2 virus and bring millions of Covid-19 diagnostic tests to market in fewer than 12 months, providing a rubric for a future pandemic response.
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