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What do we know about the function of SARS-CoV-2 proteins?
fter more than two years since the first report of COVID-19, it remains crucial to continue studying how SARS-CoV-2 proteins interact with the host metabolism to cause COVID-19. This review summarizes the findings regarding the functions of the 16 non-structural, 6 accessory and 4 structural SARS-CoV-2 proteins.
Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses
This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially…
SARS-CoV-2 variant biology: immune escape, transmission and fitness
In this Review, the authors summarize the literature on the relative transmissibility and antigenicity of SARS-CoV-2 variants, the role of mutations at the furin spike cleavage site and of non-spike proteins, the potential importance of recombination to virus success, and SARS-CoV-2 evolution in the context of T cells, innate immunity and population immunity.
National governance and excess mortality due to COVID-19 in 213 countries: a retrospective analysis and perspectives on future pandemics
National governance may have influenced the response of institutions to the Covid-19 pandemic, being a key factor in preparing for the next pandemics. The objective was to analyze the association between excess mortality due to COVID-19 (daily and cumulative per 100 thousand people) and national governance indicators in 213 countries.
Critical care and pandemic preparedness and response
This review provides an introduction to an array of topics that pertain to different states of pandemic acuity: interpandemic preparedness, alert, surge activity, recovery and relapse through the literature and experience of recent pandemics including COVID-19, H1N1, Ebola, and SARS.
Novel Influenza Vaccines: From Research and Development (R&D) Challenges to Regulatory Responses
Researchers are actively pursuing the development of next-generation and universal influenza vaccines to provide comprehensive protection against potential pandemic subtypes or strains. This review outlines the critical challenges and advancements in research and development (R&D) and highlights the improvements in regulatory responses for influenza vaccines.
